Publications
Report of the UKEMS Sub-Committee on Guidelines for Mutagenicity Testing
Part I: Basic Test Battery (1983)
Report of the UKEMS Sub-Committee on Guidelines for Mutagenicity Testing
Part II: Supplementary Tests (1984)
Comparative Genetic Toxicology - The Second UKEMS Collaborative Study.
Eds. JM Parry and CF Arlett (1985)
Statistical Evaluation of Mutagenicity Test Data
Ed. DJ Kirkland (1989)
Basic Mutagenicity Tests UKEMS recommended procedures
Ed. DJ Kirkland (1990)
Supplementary mutagenicity tests: UKEMS recommended procedures.
UKEMS sub-committee on guidelines for mutagenicity testing. Report. Part II revised. Eds. DJ Kirkland and M Fox.
Statistical Evaluation of Mutagenicity Test Data
Edited by David J. Kirkland. Cambridge University Press. 1989. ISBN 0 521 36605
This publication provides a rigorous and practical account of the design and statistical interpretation of mutagenicity tests. It highlights the statistical implications of experimental design and the topics covered include bacterial and mammalian cell colony and fluctuation assays, in vitro and in vivo chromosomal aberration tests, sister chromatid exchanges, Drosophila and dominant lethal assays. It is written by a UKEMS subcommittee, whose terms of reference were to assess the various statistical approaches available for their suitability in evaluating data from the most widely used mutagenicity tests, such that practising genetic toxicologists would be able to better understand what was required of them by regulatory authorities in this respect, and be better advised as to which forms of analysis were preferred, and why.
Basic Mutagenicity Tests: UKEMS Recommended Procedures
Edited by David J. Kirkland. Cambridge University Press. 1990. ISBN 0 521 39347 7
This volume provides a brief but important summary of the essential tests that need to be performed on all new compounds, whether they be new drugs, pesticides or food additives, before they can be registered for use in the United Kingdom. These basic tests for mutagenicity were originally drawn up by UKEMS in 1983. They have now been fully revised by expert working groups from academia and industry under the auspices of UKEMS and in collaboration with the UK Department of Health. The volume provides guidelines and recommendations for all scientists involved in the testing and registration of new compounds, not only in the UK, but in the wider international context.
The four main test procedures for measuring mutagenicity described in this volume are: bacterial mutation assays, metaphase chromosome aberration assays in vitro, gene mutation assays in cultured mammalian cells, and in vivo cytogenetics assays. Each of these tests is fully explained and described in practical and procedural detail, with additional information on the presentation and data processing of results.
Supplementary Mutagenicity Tests: UKEMS Recommended Procedures.
Edited by David J. Kirkland and Margaret Fox.. Cambridge University Press. 1993. ISBN 0 521 45073 X
This volume describes a complementary selection of tests to those described in the companion volume Basic Mutagenicity Tests (1990). These supplementary tests are used to assess risks of in vitro mutagenicity in those instances where the basic tests are inconclusive. As such, these tests have an important role in the assessment of the safety of new compounds, drugs and chemicals. The volume is therefore an essential source of reference and practical guidance for everyone involved in regulatory affairs, mutagenicity testing and the successful registration of new chemical products in the UK and the rest of Europe.